Transcriptomics and proteomics in human sleeping sickness pathogenesis and diagnosis ( DFG)
Funder: Germany African
Amount of funding: Euro 257,000.00
Duration: 3 years (April 2010-December 2013)
Principal Investigator: Professor Christine E. Clyaton
Team Leader Uganda: Professor John C.K. Enyaru
Co-Investigator Uganda: Dr. Enock Matovu
Collaboration: Research collaboration between Makerere University, Uganda and Zentrum für Molekulare Biologie, University of Heidelberg, Germany
Objectives: Study the immune and inflammatory reactions in African trypanosomiasis patients.Determine the effects of human environment on trypanosomes to provide information on human-trypanosome interactions. Characterise transcriptomes of infecting trypanosomes in order to access whether there are differences between parasites in CSF and blood.
Contribution to Makerere University
- Equipment: ELISA reader, PCR machine,
- Water bath and one WD double cabin pickup.
- Molecular reagents
- Technology transfer (Molecular biology techniques) to Makerere from Germany
- Capacity building by training two students at Ph.D levels.
More information on the pathogenesis of African trypanosomiasis obtained with a possible spill over on identification and development of molecules for diagnosis